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Ernawati, Diah Savitri
- Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in Apis mellifera Lawang Propolis Extract Gel-Treated Traumatic Ulcers in Diabetic Rats
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Authors
Affiliations
1 Department of Oral Medicine, Universitas Airlangga, Surabaya, ID
1 Department of Oral Medicine, Universitas Airlangga, Surabaya, ID
Source
Veterinary World, Vol 11, No 3 (2018), Pagination: 304-309Abstract
Aim: The aim of this study was to determine the effect of Apis mellifera propolis extract gel on vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) expression in the traumatic ulcers of rats afflicted with diabetes mellitus (DM).
Materials and Methods: The study was conducted on 24 male Wistar rats (Rattus norvegicus) induced with DM by injecting 50 mg/kg of Streptozotocin, intraperitoneally, and a traumatic ulcer on their lower lip mucosa. These were divided into eight groups: Four each for control and treatment groups. Each control and treatment group consisted of three rats. The control groups treated with hydroxypropyl methylcellulose 5% gel and treatment groups were administered with propolis extract gel. The expression of VEGF and MMP-9 was observed on days 3, 5, 7, and 9. Furthermore, mice sacrificed and the lower lip labial mucosa tissue of mice has been taken to make the histopathology anatomy preparation by means of immunohistochemical examination with monoclonal antibodies anti-VEGF and anti-MMP-9.
Results: This experiment revealed higher VEGF expression and lower MMP-9 expression in the treatment group as compared to that of the control group. Analysis of Variance showed significant differences (p<0.01) of both VEGF expression and MMP-9 expression between the two groups. A Tukey’s analysis did not find strong contrasts in VEGF and MMP-9 expressions between various treatment groups. However, those between treatment and control groups were found to be considerable.
Conclusion: Propolis extract gel increased the expression of VEGF and decreased that of MMP-9 during the healing process of traumatic ulcers on the oral mucosa of diabetes afflicted Wistar rats (R. norvegicus).
Keywords
Diabetes Mellitus, Matrix Metalloproteinase-9, Ulcer Healing Process, Vascular Endothelial Growth Factor Expression.Full Text
- Expression of FGF-2 and Fibronectin in Citrus limon Fruit Peel Malang Essential Oil Gel Treated Traumatic Ulcer in Diabetic Wistar Rats (Rattus novergicus)
Abstract Views :379 |
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Authors
Raziv Ganesha
1,
Iwan Hernawan
1,
Hening Tuti Hendarti
1,
Desiana Radithia
1,
Priyo Hadi
1,
Nurina Febriyanti Ayuningtyas
1,
Diah Savitri Ernawati
1
Affiliations
1 Department of Oral Medicine, Airlangga University, Jl. Mayjend Prof Dr. Moestopo 47 Surabaya, East Java, ID
1 Department of Oral Medicine, Airlangga University, Jl. Mayjend Prof Dr. Moestopo 47 Surabaya, East Java, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3350-3354Abstract
Diabetes Mellitus is a metabolic disease that delayed traumatic ulcer healing process. Citrus limon contains fumaric acid, d-limonene and citral that can accelerate the healing of traumatic ulcer. The aims of this study were to investigate the effect of 0.78% Citrus limon essential oil topical application can increase Fibroblast Growth Factor-2 (FGF-2) and Fibronectin expression. This study was true experimental analytic study with random sampling methods. The study was conducted on 30 male Wistar rats (Rattus novergicus) induced with DM by injecting 50 mg/kg of Streptozotocin, intraperitoneally, and a traumatic ulcer on their lower lip mucosa. These were divided into six groups; three each for control and treatment groups. Each control and treatment group consisted of five rats. The control groups treated with CMC 5% gel and treatment groups were administered with Citrus limon peel essential oil gel. The expression of FGF-2 and Fibronectin was observed on Days 5, 7 and 9. Furthermore, mice sacrificed and the lower lip labial mucosa tissue of mice has been taken to make the Histopathology Anatomy preparation by means of immunohistochemical examination with monoclonal antibodies anti-FGF2 and anti-Fibronectin. ANOVA analysis was performed to analyze the difference between group (p<0.05). The increased FGF-2 and Fibronectin expression in the treatment group as compared to that of the control group. There were significant differences (p<0.05) of both FGF2 and Fibronectin expression between the two groups. The citrus limon peel essential oil gel increased the FGF-2 and Fibronectin expression during the healing process of traumatic ulcers on the oral mucosa of diabetes afflicted Wistar rats (Rattus novergicus).Keywords
Diabetes Mellitus, Citrus limon Essential Oil Gel, Traumatic ulcer, Fibroblast Growth Factor-2, Fibronectin, Herbal Medicine.
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- Ernawati DS, Puspa A. Expression of vascular endothelial growth factor and matrix metalloproteinase-9 in Apis mellifera Lawang propolis extract gel-treated traumatic ulcers in diabetic rats. Vet World. 2018 Mar;11(3):304-309. doi: 10.14202/vetworld.2018.304-309. Epub 2018 Mar 14.
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- Topical Application of Citrus limon Peel Essential Oil Increased Pro-Inflammatory Cytokines Expression on Type IV Hypersensitivity Reaction
Abstract Views :139 |
PDF Views:76
Authors
Fatma Yasmin Mahdani
1,
Ulyasari Rachmaningayu
2,
Elva Anjani
2,
Asri Dewanti Adhi Nugrahaeni
2,
Naqiya Ayunnisa
3,
Salsabila Fitriana Putri
3,
Meircurius Dwi Condro Surboyo
1,
Nurina Febriyanti Ayuningtyas
1,
Priyo Hadi
1,
Hening Tuti Hendarti
1,
Diah Savitri Ernawati
1
Affiliations
1 Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
2 Dental Profession Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
3 Bachelor Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
1 Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
2 Dental Profession Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
3 Bachelor Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
Source
International Journal of Medical and Dental Sciences, Vol 12, No 1 (2023), Pagination: 2063-2070Abstract
Introduction: Citrus limon peels essential oil has the potential to be developed as a topical medicine due to its active components. The essential oil has been demonstrated in numerous studies to have anti-inflammatory, anti-microbial, antifungal, and antioxidant properties. A study is required to determine whether Citrus limon peel essential oil can cause a type IV hypersensitivity reaction by examining the expression of the cytokines TNF-, IL-1, and IL-6 as well as the clinical manifestations on an animal skin. In this study, the effect of topically applying the essential oil of Citrus limon peel on the expression of TNF-α, IL-1, and IL-6 as well as on type IV hypersensitivity reaction symptoms was examined. Methods: This study is based on the guinea-pig maximisation test method in NADFC RI Regulation Number 7 of 2014, with two groups (control group and treatment group) for each set of ten samples. Citrus limon peels essential oil was administered to the treatment group, whereas CMC-Na was given to the control group. Animal models were euthanized after which the tissues were prepared as specimens for immunohistochemical staining. The expression of cytokines was computed and examined using a light microscope. Results: There were no clinical signs of type IV hypersensitivity in either group, and the expression of TNF-α, IL-1 and IL-6 in the treatment group was found higher than in the control group. Conclusion: After topical administration of Citrus limon peels essential oil, there was an increase in the expression of TNF-α, IL-1 and IL-6 without any clinical symptoms of type IV hypersensitivity.Keywords
Citrus limon, Essential Oil, IL-6, TNF-α, IL-1, Type IV HypersensitivityFull Text
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